Approximately 1 in 10 people with problem gambling disorder report being concerned about their substance use, and research shows that people with a history of substance misuse are at higher risk for problem gambling. There is a complex relationship between problem gambling and substance misuse and a clear intersection between these behavioral health issues. This training explores problem gambling concepts and terminology, the similarities and differences between problem gambling and substance misuse, implications for prevention and intervention strategies, as well as opportunities for collaboration between the substance misuse and problem gambling prevention fields.