THRIVE enables communities to determine how to improve health and safety, and promote health equity. It is a framework for understanding how structural drivers, such as racism, play out at the community level in terms of the social-cultural, physical/built, and economic/ educational environments. We call these community-level indicators the community determinants of health. In addition to being a framework, THRIVE is also a tool for engaging community members and practitioners in assessing the status of community determinants, prioritizing them, and taking action to change them in order to improve health, safety, and health equity. As a framework, THRIVE is widely applicable to local, state, and national initiatives to inform policy and program direction. As a tool, THRIVE can be used in a variety of planning and implementation processes, from neighborhood-level planning to community health needs assessments (CHNA) and community health improvement planning (CHIP) processes.